A Welcome Chink in Drug Resistance
Candida filaments are usually long (L) but are “impotent” in amphotericin B-resistant strains (R).
Given the alarming news about drug-resistant super bugs, it’s a relief to know that at least one drug still works even after 50 years of clinical use. Even better, researchers think they finally know why. The drug is amphotericin B and it kills the fungus Candida albicans, a common hospital-acquired infection that can be life-threatening.
In this issue of PLOS Biology, Lindquist and colleagues show that amphotericin B-resistant Candida strains have a hard time surviving on their own, let alone against the defenses of a mammalian host… (more)
PLOS Biology 2013